Research progress on the mechanism of renal interstitial fibrosis in obstructive nephropathy

Renal fibrosis is a common result for various chronic kidney diseases developing to the end stage. It pathological process characterized by destruction of normal structure and subsequent replacement with fibrous tissue, which primarily involves fibroblast proliferation extracellular matrix deposition. Obstruction cause renal fibrosis, obstructive disease in urology. Obstructive its insidious onset, complex interplay multiple factors. These factors encompass tubular epithelial cell injury, presence hypoxic microenvironment affected inflammatory infiltration, release mediators, growth factors, among others. This paper reviews research progress on mechanism treatment interstitial fibrosis.